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Education & Experience
2003 - present
PhD student in Pharmaceutical Sciences
University of Camerino,
Italy
2002 - 2003
Fellowship in Medicinal Chemistry title” Synthesis of agonists
and antagonists for adenosine receptors”, tutor Prof. Gloria
Cristalli (University of Camerino, Italy).
1995 - 2001
Degree in Pharmaceutical Chemistry and
Technology
University of Camerino, Italy
Experimental Thesis title:” Synthesis of potent and selective radioligands for the A3 adenosine
receptor”.
Supervisor: Prof: Gloria Cristalli (University of Camerino, Italy).
Research field:
Medicinal and Pharmaceutical Chemistry
Expertise:
Nucleoside Synthesis
Publications:
1 - R.
Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K.-N.
Klotz, G. Cristalli.
“N6-Alkyl-2-alkynyl-derivates
of adenosine as potent and selective antagonists at human adenosine A3
receptor and starting point for searching of A2B ligands.”
J. Med. Chem. 2002, 45,
3271-3279.
2 - S. Vittori, D. Salvatori, R. Volpini, S.
Vincenzetti, A. Vita, S. Taffi, S.
Costanzi, C. Lambertucci, G. Cristalli.
“Deaza
and deoxy adenosine derivatives: synthesis and
inhibition of animal viruses as human infection models”
Nucleosides Nucleotides & Nucleic Acids, 22
(5-8), 877-881, 2003.
3 - S. Costanzi, S. Vincenzetti, A. Vita, C. Lambertucci, S. Taffi,
R. Volpini, S. Vittori, G. Cristalli.
“Human cytidine
deaminase: understanding the catalytic mechanism.”
Nucleosides Nucleotides & Nucleic Acids 22
(5-8), 1539-1543, 2003.
4 - C. Lambertucci, R.
Volpini, S. Costanzi, S. Taffi, S. Vittori, G. Cristalli.
“2-Phenylhydroxypropynyladenosine
derivatives as high potent agonists at A2B adenosine receptor
subtype.”
Nucleosides Nucleotides & Nucleic Acids, 22 (5-8),
809-812, 2003.
5- G. Cristalli. C.
Lambertucci, S. Taffi, S. Vittori and R. Volpini.
“Medicinal Chemistry of adenosine A2A
receptor agonists.”
Curr. Topics in Med. Chem. 3, 387-401, 2003.
6 - G. Cristalli. S. Costanzi,
C. Lambertucci, S. Taffi, S. Vittori, R. Volpini,
“Purine and deazapurine nucleosides:
synthetic approacheas, molecular modeling, and
biological activity”
Il Farmaco 58,
193-204, 2003,
7- S. Vittori,
S. Costanzi, C. Lambertucci, F. R. Portino, S.
Taffi, R. Volpini, K.-N. Klotz, G. Cristalli.
"A2B adenosine receptor
agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl
adenosine and NECA derivatives."
Nucleosides Nucleotides & Nucleic Acids, 23
(1-2), 471-481, 2004.
8 - R. Volpini, S.
Costanzi, C. Lambertucci, F. R. Portino, S.
Taffi, S. Vittori, J. A. Zablocki, K.-N.
Klotz, G. Cristalli, "Adenosine receptor agonists:synthesis
and binding affinity of 2-(aryl)alkylthioadenosine
derivatives." ARKIVOC,
(v), 2004, 301-311.
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